Solicitation
Biomedical Advanced Research and Development Authority (BARDA) Broad Agency Announcement (BAA)
Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response · Sol. BAA-23-100-SOL-00004
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AI summary Beta
Some details weren't available to this summary, so it may miss requirements. Check the attachments on SAM.gov.
The Biomedical Advanced Research and Development Authority (BARDA), part of HHS's preparedness office, runs an open Broad Agency Announcement (a standing call for R&D proposals) for medical countermeasures such as vaccines, antivirals, antimicrobials, diagnostics and treatments for chemical, biological, radiological and nuclear threats and emerging infectious diseases. The current version is Amendment 7, posted March 19, 2026, and the final proposal deadline for open areas of interest is September 25, 2028. Proposals go through a multi-step process (a pre-submission call, a short abstract, then a full proposal), and much of the detail sits in portions of the BAA that were not included in the text provided.
Watch out for
- Specialized biomedical R&D. Proposals need credible scientific and technical content, key personnel and typically regulatory and manufacturing plans, which is a high bar for a small business without life-science experience.
- Multi-stage process before a full proposal. You must first hold a pre-submission call and send a quad chart and market research abstract, so the real timeline starts well before the final deadline.
Pre-Submission Call and Quad Chart/Market Research Abstract Instructions
- Foreign ties and supply chain disclosures. Offerors must disclose foreign ownership, affiliations, leadership ties, litigation and bankruptcy history, which can lead to a non-responsible finding if incomplete.
Offeror to furnish the information required in this provision or provide additional information as
- Domestic manufacturing and gain-of-function considerations. Amendment 6 added these as extra evaluation considerations, which may affect where and how work can be done.
Domestic Based Manufacturing
- Cost or pricing data certification. The BAA includes a certificate that cost or pricing data is accurate, complete and current, which brings accounting-system and audit exposure.
Certificate of Current Cost or Pricing Data
Read from the notice and 12 attachments. 3 not read in full.
- BARDA FY23 Modernized BAA Solicitation - Amendment 7.pdf
- BARDA FY23 Modernized BAA Solicitation - Amendment 6.pdf
- BARDA FY23 Modernized BAA Solicitation - Amendment 5.pdf
- BARDA FY23 Modernized BAA Solicitation - Amendment 4.pdf
- BARDA FY23 Modernized BAA Solicitation - Amendment 3.pdf
- BAA-23-100-SOL-00004 Amendment 2.pdf
- BAA-23-100-SOL-00004 Amendment 1.pdf
- BARDA BAA-23-100-SOL-00004.pdf
- Amendment_7_Changes_Table.pdf
- Amendment_6_Changes_Table.pdf
- Amendment_5_Changes_Table.pdf
- Amendment_4_Changes_Table.pdf
- Amendment_3_Changes_Table.pdf: over the file limit for one brief
- Amendment_2_Changes_Table.pdf: over the file limit for one brief
- Amendment_1_Changes_Table.pdf: over the file limit for one brief
Full brief
What they want
- Research and development of medical countermeasures (MCMs) for chemical, biological, radiological and nuclear (CBRN) threats, pandemic influenza and other emerging infectious diseases
- CBRN vaccines, antivirals and antitoxins, and antimicrobials (areas of interest 1 to 3)
- Radiological/nuclear, chemical, and burn and blast medical countermeasures (areas 4 to 6)
- Diagnostics (area 7)
- Influenza and emerging infectious disease vaccines and therapeutics (areas 8 and 9)
- ImmuneChip+ (area 10) and Flexible and Strategic Therapeutics, FASTx (area 12, reopened in Amendment 7)
- Note: area 11 (COVID-19 Immune Assay development) is listed as suspended
- Contract type
- Broad Agency Announcement (research and development). The type of award is described in a section that was not included in the text provided.
- Place of performance
- USA
- Contract vehicle
- BARDA Broad Agency Announcement BAA-23-100-SOL-00004 (Amendment 7)
- How they'll choose
- Proposals are reviewed against factors listed in the BAA table of contents (plus other considerations); weighting and rating details are in a section that was not included in the text provided.
- Offers due
- September 25, 2028, 4:30 PM Eastern Time (final proposal deadline for open areas of interest)
- How to submit
- Contracting questions go to BARDA-BAA@hhs.gov. The BAA has an electronic portal submission section, but its instructions were not in the text provided.
What they'll judge offers on
- Program Relevance
- Overall Scientific and Technical Merits of the Proposal
- Offeror's Capabilities and Related Experience, including the qualifications, capabilities and experience of the proposed key personnel
- Other evaluation factors and considerations (Amendment 6 added Gain of Function Research and Domestic Based Manufacturing)
What to include when you submit
- Stage 1: pre-submission call with the technical point of contact for your area of interest
- Stage 2: submit a Quad Chart and Market Research Abstract, which BARDA assesses before inviting a full proposal
- Stage 3: full proposal, with a technical volume (Volume I) and a cost volume with attachments (Volume II)
- Volume II includes a Supply Chain Risk Assessment attachment, and the representations on foreign ownership and ties must be completed
- Place a copy of the Government notice for handling proposals (Appendix 1) behind the title page of each copy of the technical proposal
- Include the Certificate of Current Cost or Pricing Data (Appendix 2) where cost or pricing data is required
- Contracting questions for FASTx should use the subject line format 'Contracting questions: AOI 12 (FASTx): <brief description>' (from earlier versions of the BAA)
You must have
- Supply chain risk assessment: disclose foreign ownership, foreign affiliations, government ties, export-control and debarment history; findings can affect responsibility and eligibility for award
Findings from the supply chain risk assessment will be considered
- State whether any foreign owner controls more than 10 percent of the company's shares
does not have any foreign ownership, outside of retail shareholders, who control
- Supply chain information and representations must also be flowed down to, and collected from, subcontractors providing mission-critical products or services
The Offeror shall submit all potential subcontractor
- Who may submit is described under 'Eligible Offerors' in the BAA, which was not in the text provided. The SAM.gov listing shows no set-aside.
Not in the notice text
- Eligible offerors, type of award and number of awards (sections not included in the text provided)
- Funding amounts, award sizes and periods of performance
- Page limits and file formats for the quad chart, abstract and proposal volumes
- Electronic portal name and exact submission steps
- Evaluation weighting and rating scale
- Area-of-interest requirements and technical contacts (most of Part VIII was left out; AOI 12 FASTx text shown is from earlier amendments and may have changed in Amendment 7)
- Whether small businesses get any preference (no set-aside is shown)
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Key facts
- Response due
- Sep 25, 2028, 8:30 PM UTC
- Posted
- Mar 20, 2026
- Notice type
- Solicitation
- Solicitation
- BAA-23-100-SOL-00004
- Agency
- Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response
- Office
- Barda - Aspr / Daappo / Barda DCMA
- NAICS
- 541714
- Product/service code
- AN13
- Business type
- Engineering, architecture & research
- Contracting contact
- BARDA-BAA@hhs.govBARDA-BAA@hhs.gov
- Versions
- 10 (amended since first posted)
What similar contracts paid
143 contracts at this agency for the same NAICS and product/service codes had activity in the last 5 years, according to USAspending.gov. Small businesses won 22% of the dollars in this market over the last 3 fiscal years.
Typical contract$6MMiddle half: $741K to $22.3M
Typical per year$1.4MValue divided by years of performance
Before you respond
Full notice text from SAM.gov
We appreciate your interest in partnering with BARDA. The latest BARDA Broad Agency Announcement (BAA) is Amendment 7 posted on March 19, 2026. All contracting-related inquiries should be sent to BARDA-BAA@hhs.gov. The final proposal submission deadline is September 25, 2028, at 4:30 PM Eastern Time for open areas of interest.
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