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Small business government contractors

Profiles of small businesses registered on SAM.gov to win federal contracts: CAGE code, UEI, registration status, SBA certifications and federal contract history. 34,768 of them have won federal contracts or SBIR/STTR awards in the last few years.

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Small businesses in California, with primary NAICS code 541714 (Research and Development in Biotechnology (except Nanobiotechnology)), by federal contract dollars

Ranked by federal prime contract dollars as a small business since FY2024 (USAspending.gov, as of Nov 5, 2026). The 50 with the most dollars are shown; add a filter to narrow the list.

How these are ranked

Prime contract dollars since fiscal year 2024 on contracts where USAspending.gov counts the firm as a small business. “Small” is set per NAICS code: these firms are registered small under their primary code (or SBA-certified). Firms that hold small business subcontracting plans, which only businesses that aren't small file, or have $1 billion or more in these contracts are left out. A profile's yearly totals count all of its prime contracts, so they can be higher.

  1. 4J Therapeutics IncPalo Alto, CA · $63.1 million
  2. Revagenix IncSan Mateo, CA · $32.8 million
  3. EITR Biologics, Inc.San Diego, CA · $28.4 million
  4. Dnanexus, Inc.Mountain View, CA · $13 million
  5. Primmune Therapeutics, Inc.Carlsbad, CA · $11.3 million
  6. Vaxart Biosciences IncSouth San Francisco, CA · $9.3 million
  7. Lumos Diagnostics, IncCarlsbad, CA · $9.2 million
  8. Aspera Biomedicines, Inc.La Jolla, CA · $6.5 million
  9. Auxilium Biotechnologies Inc.San Diego, CA · $5.7 million
  10. Biospyder Technologies, Inc.Carlsbad, CA · $5.1 million
  11. Molecular Express, IncRancho Dominguez, CA · $5 million
  12. Anivive Lifesciences IncLong Beach, CA · $4.9 million
  13. RC Integrated Systems LLCTorrance, CA · $3.9 millionWOSB
  14. Novomedix LLCSan Diego, CA · $3 millionWOSB
  15. Bifrost Biosystems IncBerkeley, CA · $2.5 million
  16. Qoolabs IncCarlsbad, CA · $1.8 millionWOSB
  17. Exodigm Biosciences, Inc.Portola Valley, CA · $1.7 million
  18. Seqmatic, LLCFremont, CA · $1.5 million
  19. Capture Bioscience Inc.Menlo Park, CA · $749,999
  20. In Diagnostics, Inc.Carlsbad, CA · $749,000
  21. Gator Bio IncPalo Alto, CA · $666,160
  22. Vivid Bioinnovations, PBCSan Francisco, CA · $595,337
  23. Gencyte Therapeutics IncSan Carlos, CA · $499,990
  24. Pearson Pharma PartnersWestlake Village, CA · $350,652
  25. Kairu Therapeutics Inc.Alameda, CA · $350,000
  26. Edge Biosystems IncSan Jose, CA · $322,770
  27. Immport Therapeutics IncIrvine, CA · $300,000
  28. Tippingpoint Biosciences, Inc.Los Altos, CA · $300,000WOSB
  29. Spectral Platforms IncDuarte, CA · $290,377
  30. Mission Bio, IncSouth San Francisco, CA · $235,051
  31. Quick Biology IncMonrovia, CA · $167,949
  32. Ultima Genomics, Inc.Fremont, CA · $166,358
  33. Synthego Holdings LLCRedwood City, CA · $140,000
  34. Exodus Bio Inc.San Jose, CA · $132,000
  35. Invetech US LLCSan Diego, CA · $124,000
  36. Dalton Bioanalytics Inc.Los Angeles, CA · $123,400
  37. Doubleshot IncSanta Rosa, CA · $104,891
  38. Iggenix, Inc.South San Francisco, CA · $100,000
  39. Sapient Bioanalytics, LLCSan Diego, CA · $99,500
  40. Reblood RX, Inc.San Diego, CA · $74,881
  41. Zymo Research CorporationIrvine, CA · $69,623WOSB
  42. Polypeptide Laboratories San Diego, LLCSan Diego, CA · $61,825
  43. Antibody SolutionsSanta Clara, CA · $52,550
  44. Chapter Diagnostics Inc.Menlo Park, CA · $48,390
  45. Christoph KahlThousand Oaks, CA · $47,500
  46. Stemexpress, LLCFolsom, CA · $42,174WOSB
  47. OZ Biosciences USA, IncSan Diego, CA · $24,990
  48. Dovetail Genomics LLCScotts Valley, CA · $24,888
  49. DC3 Therapeutics, LLCSouth San Francisco, CA · $24,400
  50. Ridge Diversified Holdings LLCCarmichael, CA · $21,870
Top firms by certification in California, with primary NAICS code 541714 (Research and Development in Biotechnology (except Nanobiotechnology)) (WOSB)

Top Women-owned small businesses in California, with primary NAICS code 541714 (Research and Development in Biotechnology (except Nanobiotechnology))

  1. RC Integrated Systems LLCTorrance, CA · $3.9 million
  2. Novomedix LLCSan Diego, CA · $3 million
  3. Qoolabs IncCarlsbad, CA · $1.8 million
  4. Tippingpoint Biosciences, Inc.Los Altos, CA · $300,000
  5. Zymo Research CorporationIrvine, CA · $69,623
  6. Stemexpress, LLCFolsom, CA · $42,174
  7. Edna Explorer, IncMountain View, CA · $14,364
  8. Mybiosource IncSan Diego, CA · $11,410

Hiring small subcontractors?

If you're a prime looking for small businesses to team with, use the filters above to list small firms by state, NAICS code and certification, then open a profile for its SAM.gov registration, the codes it is small under and its contract history. Check any firm by name, UEI or CAGE code with the CAGE code and UEI lookup.

About these profiles

Every business registered on SAM.gov as small under at least one NAICS code, and every SBA-certified firm, has a profile; each profile says which codes it is small under. Registration details come from SAM.gov's public entity extract and contract figures from USAspending.gov. Contact names and street addresses are left out. Looking for partners to team with? See how to become a government subcontractor.

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