Spero Therapeutics, Inc.
Spero Therapeutics, Inc. is a small business in Cambridge, MA registered on SAM.gov to bid on federal contracts. It has won about $21.6 million in federal prime contracts since fiscal year 2024, according to USAspending.gov's award records for its UEI.
- UEI
- NX34PL7NZW24
- CAGE code
- 7SK81
- SAM.gov registration
- Active
Federal contract history
| Fiscal year | Obligated, prime contracts |
|---|---|
| FY2024 | $15.8 million |
| FY2025 | $6.4 million |
| FY2026 (incomplete) | -$537,178 |
FY2026 ended September 30, and its year-end contract reports and corrections are still arriving, so it's marked incomplete until about early January 2027.
These are every prime contract USAspending.gov records under UEI NX34PL7NZW24, from its award search. For a company that is part of a parent company, USAspending's recipient page can show a different figure for a year, because it counts the company's own record and its parent's record separately.
A negative year means cuts to older contracts (de-obligations, often when work finishes under budget or is descoped) took off more than new awards added.
Its biggest federal customers since fiscal year 2024: Office of Assistant Secretary for Preparedness and Response ($18.2 million) and National Institutes of Health ($3.4 million).
Recent contract awards
New contracts, by the date each was first signed. Orders and changes to older contracts count in the yearly totals above but aren't listed here, and Defense awards appear 90 days after signing.
| Awarded | Agency | What it's for | Obligated |
|---|---|---|---|
| May 12, 2021 | National Institutes of Health | To advance clinical and non-clinical development of an antibiotic candidate. | $10.5 million |
| Jul 12, 2018 | Office of Assistant Secretary for Preparedness and Response | 75A50118C00015 | $49.2 million |
| Jun 30, 2015 | National Institutes of Health | "development of a second generation polymyxin for therapy of MDR gram-negative infections" | $5.9 million |
Figures are prime contract obligations reported to USAspending.gov. Work done as a subcontractor isn't included.
SBIR and STTR awards
Spero Therapeutics, Inc. has won 1 small business R&D award worth $989,896 through the SBIR and STTR programs since 2017, 1 of them Phase II. Funded by NIH.
| Awarded | Agency | Project | Amount |
|---|---|---|---|
| Mar 1, 2017 | NIH | SBIR Phase II A Novel Gyrase Inhibitor for the Treatment of Drug-susceptible and Multidrug-resistant… | $989,896 |
Award data from SBIR.gov. SBIR and STTR awards are grants or contracts for R&D, so some don't appear in its federal contract history.
Registration details
Show registration details
From SAM.gov's monthly public file dated Nov 1, 2026. If the business has updated its registration since, SAM.gov shows the newer details.
| Legal business name | Spero Therapeutics, Inc. |
|---|---|
| Unique Entity ID (UEI) | NX34PL7NZW24 |
| CAGE code | 7SK81 |
| Location | Cambridge, MA |
| SAM.gov registration | Active through Jul 2, 2027 |
| Business started | 2013 |
| Primary NAICS code | 541715: Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) |
| How to contact | No phone or email in SAM.gov's public file. Search UEI NX34PL7NZW24 in SBA's Small Business Search for a contact the business added. |
Certifications and business types
No SBA certification (8(a), HUBZone or WOSB) in SAM.gov's public file (Nov 1, 2026).
SBA certifications let a business compete for set-aside contracts (set-asides explained). Check the current record on its SAM.gov entry.
How to check or correct this record
The file sometimes leaves a certification out, and a newer one won't be in it yet.
Check or correct this record at the source: open its SAM.gov entry, or search UEI NX34PL7NZW24 () in SAM.gov's entity search (free sign-in) and in SBA's Small Business Search (formerly DSBS), which shows SBA certifications. The business can update its details in its SAM.gov registration and its certifications at certifications.sba.gov.
NAICS codes Spero Therapeutics, Inc. is small under
On its SAM.gov registration, Spero Therapeutics, Inc. meets the SBA size standard for these industries, so it can bid on small business set-asides that use them.
Open contracts in Spero Therapeutics, Inc.'s NAICS codes
254 open federal opportunities on SAM.gov use one of Spero Therapeutics, Inc.'s NAICS codes and may be open to it: no set-aside, or, in the codes it is registered small under, a small business set-aside. Here are a few, those in its primary code first, then those in Massachusetts, then the soonest due.
- Global Aircrew Strategic Network Terminal Increment 2, Block 2 (GASNTi2b2) Industry Day
Event or sign-up Nov 24, 2026An event or its sign-up, not a bid deadline.
- Broad Agency Announcement for Basic and Applied Research at the US Army Combat Capabilities Development Command - Soldier Center
✦ The U.S. Army DEVCOM Soldier Center (Natick, MA) is running a long-open Broad Agency Announcement (BAA), a standing call for research ideas, across soldier-focused science and…
Open until Feb 27, 20304:30 AM EST
- Research and Development (R&D) for Next Generation Aircraft Protection Technologies
Due Nov 23, 2030 (check date)More than 3 years away, which is unusual. Check the date on SAM.gov.
- Aircraft Defensive Electro-optical Protection Technologies (ADEPT)
✦ Required first step for solicitation FA2377-26-R-B011, due November 6, 2026, 12:00 PM Eastern: email the contracting contacts your CAGE (Commercial and Government Entity) code to…
Due in 2 daysNov 9, 2026, 2:00 PM ESTThe AI summary flags this date. Check SAM.gov.
- Protein Palace Proposers Day
Event or sign-up Nov 9, 2026An event or its sign-up, not a bid deadline.
Similar small businesses
Other small businesses of a similar size with the same primary NAICS code (541715) that have won federal contracts in Massachusetts:
- A10 Systems Inc, Lowell, MA
- Boston Fusion Corp, Lexington, MA
- Teradar, Inc., Boston, MA
- Specter Aerospace Inc., Peabody, MA
- FTL Labs Corp, Amherst, MA
- Interactive Aptitude LLC, Tyngsboro, MA
Is this your business? Get a reminder before the SAM.gov registration expires
Get a reminder before the SAM.gov registration expires. It's active through Jul 2, 2027. We'll email you 60, 30 and 7 days ahead, and if it lapses.
Frequently asked questions
What is Spero Therapeutics, Inc.'s CAGE code?
Spero Therapeutics, Inc.'s CAGE code is 7SK81. The Defense Logistics Agency assigns CAGE codes when a business registers on SAM.gov.
What is Spero Therapeutics, Inc.'s UEI?
Spero Therapeutics, Inc.'s Unique Entity ID (UEI) is NX34PL7NZW24. SAM.gov assigns the UEI, and it identifies the business across the federal government.
Is Spero Therapeutics, Inc.'s SAM.gov registration active?
Yes, as of SAM.gov's public data from Nov 1, 2026, Spero Therapeutics, Inc.'s registration is active through Jul 2, 2027. Registrations are renewed every year.
Is Spero Therapeutics, Inc. a small business?
Spero Therapeutics, Inc. is registered on SAM.gov as small under 2 NAICS codes, including its primary code, 541715. Size is set per NAICS code, so a business can be small for some contracts and not others.
Keep going
- Look up another business's CAGE code or UEI
- Check a SAM.gov registration's status
- How to become a government subcontractor
- Hiring subcontractors? List small businesses by state, NAICS code and certification
Registration details come from SAM.gov's public entity extract and contract figures from USAspending.gov. Contact names and street addresses are left out. To change these details, update the registration on SAM.gov. To report a mistake on this page, or to ask us to remove it, email hello@fedready.us with the page address; we reply within 2 business days. For a removal, write from an address at the company.